iGene® Non-Invasive Prenatal Test (NIPT) that analyses cell-free fetal DNA (cffDNA) present in maternal blood. This DNA comes from the placenta and circulates freely in the maternal bloodstream.
iGene® Non-Invasive Prenatal Test (NIPT) that analyses cell-free fetal DNA (cffDNA) present in maternal blood. This DNA comes from the placenta and circulates freely in the maternal bloodstream.
iGene® NIPT screens for Trisomy 21 (Down Syndrome), Trisomy 18 (Edward Syndrome), Trisomy 13 (Patau Syndrome), Sex Chromosome Aneuploidies and selected Deletions1.
iGene® NIPT can detect Trisomy 21, 18, 13, Sex Chromosome Aneuploidies and selected Deletion Syndromes. iGene® NIPT can be performed on expectant mothers who may be considering, or have been offered, prenatal testing for fetal trisomy2.
Trisomy Aneuploidies 1
Sex Chromosome Aneuploidies 3
Trisomy X (Triple X Syndrome)
Monosomy X (Turner Syndrome)
XXY (Klinefelter Syndrome)
XYY (Jacobs Syndrome)
Deletion/Duplication Syndromes *
Additional Trisomies *
Trisomy 9
Trisomy 16
Trisomy 22
Fetal Sex *
Information on fetal sex will be reported if requested.
Medical treatment has to be individualised and can only be rendered after adequate assessment of your condition through appropriate clinical examination, and after discussion with your doctor. You should not rely on the information provided herein. Please note that the contents of this page are provided on the understanding that no surgical or medical advice or recommendation is being rendered.
Sources:
1. Zhang et al.,Ultrasound Obstet. & Gynecol 2015
2. Liu H, et al., PLoS One 2016.
3. Jiang F, et al. BMC Medical Genomics, 2012, 5:57.
* Based on in-silico data.
Non-invasive prenatal testing (NIPT) is a simple blood test performed during pregnancy. It analyses cell-free fetal DNA circulating in the mother’s blood to detect genetic abnormalities such as Down syndrome. The test is safe, poses no risk to the baby, and provides highly accurate results, which is then sent to a laboratory for analysis. Results are usually available within a week, giving parents valuable information about their baby’s health early in the pregnancy.
When Emily found out she was pregnant, joy quickly turned to worry. Her family history of genetic conditions made her pregnancy high-risk. She had initially heard about invasive testing, which involved needles and carried a risk of miscarriage. The thought of it filled Emily with dread and anxiety. Then, she learned about non-invasive prenatal testing (NIPT). A simple blood draw from her arm, no risk to her baby, and accurate results. Choosing NIPT allowed Emily to feel at ease, knowing she could monitor her baby’s health without the fear and stress of invasive procedures. When her results came back normal, the relief was immense, allowing her to enjoy her pregnancy with peace of mind.
iGene® Non-Invasive Prenatal Test (NIPT)
More than 11 million iGene® NIPT samples processed over 100 countries globally.1
Over 1.93 million pregnancies clinical study done worldwide – established through rigorous validation in a single multicentre NIPT study using iGene® technology platform2.
Importance of Prenatal Testing – Proactive approach to prenatal care
Trisomy 21, 18 and 13 are three of the most common chromosomal abnormalities, usually due to the presence of one extra copy of chromosome 21, 18 or 13. iGene® NIPT test is designed to screen for the risk that the fetus is affected by these trisomies, as well as other rare abnormalities including Sex Chromosome Aneuploidies, specified Deletion Syndromes (small missing sections of specified chromosomes)3 and Additional Trisomies. If you wish to find out information on these additional abnormalities, you may choose accordingly.
iGene® Non-Invasive Prenatal Test has an overall detection rate of 99% for Trisomy 21, Trisomy 18 & Trisomy 13 and a False Positive rate of 0.05%4. The test delivers a Positive Predictive Value (PPV) of 92.2% for Trisomy 21 based on a published study of more than 146,000 pregnancies3. If requested, iGene Laboratory will report information on fetal sex for aid in the risk assessment of X-linked disorders.
Description:
Down Syndrome is a genetic condition caused by the presence of an extra copy of chromosome 21 in a person’s cells.
Common symptoms and features:
– Distinct physical features like flat face and almond-shaped eyes and a short neck
– Intellectual and developmental delays
– Increased risk of heart defects and respiratory issues and a higher risk of certain medical conditions
Description:
Edwards Syndrome, also known as Trisomy 18, is a genetic disorder caused by the presence of an extra copy of chromosome 18 in a person’s cells. The severity of the condition varies, and some individuals may exhibit a broader range of abilities than others.
Common symptoms and features:
– Severe intellectual and developmental delays and developmental disabilities
– Multiple congenital anomalies affecting various organs
– Heart defects and low birth weight
– Distinct facial features like clenched fists with overlapping fingers, small jaw and ears
Description:
Patau Syndrome, also known as Trisomy 13, is a chromosomal disorder characterized by the presence of an extra copy of chromosome 13 in a person’s cells.
Common symptoms and features:
– Severe intellectual and developmental delays
– Physical abnormalities like cleft lip/palate and extra fingers/toes
– Multiple congenital anomalies affecting various organs
– Heart defects, brain abnormalities
Source:
iGene Laboratory Private Limited
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The Capricorn, Singapore 117528
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HCI Number: 17I0382
CAP Number: 8124837
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Tel: +65 6995 2442
Fax: +65 6873 0240
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